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Pelvic Pain/IC May Respond to Dextroamphetamine Sulfate, Despite Previous Treatment Failure

Check JH. Sympathomimetic amines are a safe, highly effective therapy for several female chronic disorders that do not respond well to conventional therapy. Clin Exp Obstet Gynecol. 2015;42(3):267-78.

This study suggests that dextroamphetamine sulfate, a stimulant sometimes used to treat attention deficit hyperactivity disorder (ADHD), is highly effective in women with pelvic pain and other chronic disorders that have persisted despite conventional medical therapy or surgery. Women in the study were treated with dextroamphetamine sulfate at a dose of 15 mg, though the dose sometimes was increased depending on how the patient was responding to treatment and how the treatment was being tolerated. The results suggest that a high percentage of women had improvement of symptoms on this treatment. The investigators suggest that dextroamphetamine sulfate may have a promising role not only in treatment of interstitial cystitis (IC) and pelvic pain, but also for women who experience severe headaches, inflammatory bowel disease, fibromyalgia, chronic fatigue syndrome, urticaria, and other disorders.