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Overactive Bladder Features May Vary Due to Underlying Conditions

Patra PB, Patra S. Research Findings on Overactive Bladder. Curr Urol. 2015 May;8(1):1-21. doi: 10.1159/000365682. Epub 2015 May 20.

This educational article provides a comprehensive review of the conditions that lead to overactive bladder (OAB), including diabetes, multiple sclerosis, stress, depression, interstitial cystitis, and more. These conditions all may lead to structural and functional changes, not only in the lower urinary tract, but also in the brain and spinal cord. Interestingly, when OAB patients are analyzed, the changes that occur vary widely, suggesting that the disease processes underlying OAB may be different for each condition. Both human and animal studies are discussed in this review article; the analysis provided by the authors might be helpful for guiding further research into new or existing therapies designed to treat OAB.