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Hyaluronic Acid Efficacy Encouraging in Small Series of Patients IC/BPS

Han XM, Wu XH, Li B, Pan F, Li WC, Liu SL, Zeng FQ, Chen M. The effects of intravesical therapy with hyaluronic acid for painful bladder syndrome: Preliminary Chinese experience and systematic review. Taiwan J Obstet Gynecol. 2015 Jun;54(3):240-7. doi: 10.1016/j.tjog.2014.09.007.

This study describes the use of intravesical hyaluronic acid in Chinese patients with interstitial cystitis/bladder pain syndrome (IC/BPS). The preliminary results include a series of 13 patients with IC/BPS who received hyaluronic acid as first-line therapy. They were treated once weekly for 4 weeks, and then once a month for a total of 4 months. Encouragingly, the investigators reported a significant decrease in symptoms after treatment, as measured by the often-used O’Leary-Sant Interstitial Cystitis Symptom Index (ICSI). Likewise, they reported a decrease in voiding frequency, increase in bladder capacity, and improvement in scores on the Interstitial Cystitis Problem Index (ISPI). These findings suggest intravesical hyaluronic acid potentially can be an effective treatment for patients with IC/BPS.