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Chen X, Zhou Z, Qiu X, Wang B, Dai J. The Effect of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) on Erectile Function: A Systematic Review and Meta-Analysis. PLoS One. 2015 Oct 28;10(10):e0141447. doi: 10.1371/journal.pone.0141447. eCollection 2015.

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Li HJ, Kang DY. Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis. World J Urol. 2015 Nov 6. [Epub ahead of print]

In two recently published systematic reviews of studies to date, researchers determined that chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a risk factor for erectile dysfunction. The first review included a variety of higher-quality case control, cohort, and cross-sectional studies that had included more than 30,000 patients in total. Based on meta-analysis of these studies, researchers reported a strong correlation between CP/CPPS and ED, along with a significant decrease in scores on the International Index of Erectile Function (IIEF-5) Questionnaire among the patients with CP/CPPS as compared with control subjects. Based on these findings, the researchers said that it is “necessary” to assess erectile function in CP/CPPS patients, though they indicated that further studies are needed to confirm the relationship between CP/CPPS and ED. In the second recently published study, a meta-analysis of 24 studies that included more than 11,000 subjects, researchers reported a high prevalence of sexual dysfunction in men with CP/CPPS. Moreover, the prevalence of erectile dysfunction had an increasing trend in recent years, investigators added.