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Literature Reviews>Treatments/Drug Discovery

Fulranumab vs. Placebo for the Treatment of IC/PBS

Wang, H., Russell, L. J., Kelly, K. M., Wang, S., & Thipphawong, J. (2017). Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study. BMC…

Recent Trial Fails to Effectively Compare DMSO and Chondroitin Sulphate 2% Bladder Instillations for IC/PBS

Tutolo, Manuela, Ammirati, Enrico, Castagna, Giulia, Klockaerts, Katrien, Plancke, Hendrik, Ost, Dieter, Aa, Frank Van der, & Ridder, Dirk De. (2017). A prospective randomized controlled multicentre trial comparing intravesical DMSO…

Pulsed Radiofrequency May Provide Relief When Other IC Treatments Fail

Kim JH, Kim E, Kim BI. Pulsed radiofrequency treatment of the superior hypogastric plexus in an interstitial cystitis patient with chronic pain and symptoms refractory to oral and intravesical medications…

Chondroitin Sulfate Treatment is Feasible, With Fewer Side Effects Than DMSO, in Women With IC/BPS

Tutolo M, Ammirati E, Castagna G, Klockaerts K, Plancke H, Ost D, Van der Aa F, De Ridder D. A prospective randomized controlled multicentre trial comparing intravesical DMSO and chondroïtin…

Hyaluronic Acid/Chondroitin May Be Superior to DMSO in Women with IC/BPS, Study Finds

Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, Pappagallo GL. A randomized, open-label, multicenter study of the efficacy…

Prior Back Surgery Not A Problem for IC/BPS Patients Who Need Neuromodulation

Bartley JM, Killinger KA, Boura JA, Gupta P, Gaines N, Gilleran JP, Peters KM. The impact of prior back surgery on neuromodulation outcomes: A review of over 500 patients. Neurourol…

Surgical Technique for IC/BPS Works Better When Combined with Hydrodistention

Lee SW, Kim WB, Lee KW, Kim JM, Kim YH, Lee B, Kim JH. Transurethral Resection Alone Versus Resection Combined with Therapeutic Hydrodistention as Treatment for Ulcerative Interstitial Cystitis: Initial…

High-Level Review of Studies Suggests Promise of Botulinum Toxin for IC/BPS

Wang J, Wang Q, Wu Q, Chen Y, Wu P. Intravesical Botulinum Toxin A Injections for Bladder Pain Syndrome/Interstitial Cystitis: A Systematic Review and Meta-Analysis of Controlled Studies. Med Sci…

Is Botulinum Toxin the Best Intravesical Treatment for IC?

Zhang W, Deng X, Liu C, Wang X. Intravesical treatment for interstitial cystitis/painful bladder syndrome: a network meta-analysis. Int Urogynecol J. 2016 Sep 10. [Epub ahead of print] Intravesical instillation…

Hyaluronic Acid Treatments May Improve Symptoms and Quality of Life

Pyo JS, Cho WJ. Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome. Cell Physiol Biochem. 2016;39(4):1618-1625. Epub 2016 Sep 15.…