News & Blog
New Research Shows How Ketamine Abuse Causes Bladder Damage
Baker SC, Shabir S, Georgopoulos NT, Southgate J. Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress. Am J Pathol. 2016 Mar 16.…
Pain Pathway Study Reveals Potential New Targets for IC/BPS Treatment
Kouzoukas DE, Ma F, Meyer-Siegler KL, Westlund KN, Hunt DE, Vera PL. Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1. PLoS One. 2016 Mar 24;11(3):e0152055. doi: 10.1371/journal.pone.0152055.…
Bladder Pain Linked to Changes in Brain Function
Sadler KE, Kolber BJ. Urine trouble: Alterations in brain function associated with bladder pain. J Urol. 2016 Feb 20. pii: S0022-5347(16)00365-7. doi: 10.1016/j.juro.2015.10.198. [Epub ahead of print] The authors of…
JNK Pathway Could Be Implicated in Development of IC/BPS
Zhao J, Wang L, Dong X, Hu X, Zhou L, Liu Q, Song B, Wu Q, Li L. The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis…
New Alternatives to Morphine May Reduce Pain Sensitivity, With Limited Side Effects
Zadina JE, Nilges MR, Morgenweck J, Zhang X, Hackler L, Fasold MB. Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine.…
Gender Differences in Stress Response May Explain Preponderance of IC in Women
Mohammadi E, Prusator DK, Healing E, Hurst R, Towner RA, Wisniewski AB, Greenwood-Van Meerveld B. Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle…
Anti-NGF Therapy: A Potentially Effective Treatment for Bladder Symptoms?
Kawamorita N, Yoshikawa S, Kashyap M, Tyagi P, Arai Y, Chancellor MB, Yoshimura N. Liposome-based Intravesical Therapy targeting Nerve Growth Factor (NGF) ameliorates Bladder Hypersensitivity in Rats with Experimental Colitis.…
Potential Pain Mechanisms Elucidated in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Liu YJ, Song GH, Zhang C. [Prostatic inflammation-induced chronic pelvic pain: Roles of substance P and c-fos in the spinal cord]. [Article in Chinese] Zhonghua Nan Ke Xue. 2015 Aug;21(8):681-6.…
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