TRPV1-Targeted Gene Therapy: Novel Treatment for IC/BPS?

Majima T, Funahashi Y, Takai S, Goins WF, Gotoh M, Tyagi P, Glorioso JC, Yoshimura N. Herpes Simplex Virus Vector-Mediated Gene Delivery of Poreless TRPV1 Channels Reduces Bladder Overactivity and Nociception in Rats. Hum Gene Ther. 2015 Aug 31. [Epub … Continued

Researchers Link IC/BPS Tissue Impairment to Expression of Prostaglandin E2

Marentette JO, Hurst RE, McHowat J. Impaired Expression of Prostaglandin E2 (PGE2) Synthesis and Degradation Enzymes during Differentiation of Immortalized Urothelial Cells from Patients with Interstitial Cystitis/Painful Bladder Syndrome. PLoS One. 2015 Jun 9;10(6):e0129466. doi: 10.1371/journal.pone.0129466. eCollection 2015. Prostaglandin E2 … Continued

P2X Receptors Could be Promising Target in Treatment of IC/BPS

Kennedy C. ATP as a cotransmitter in the autonomic nervous system. Auton Neurosci. 2015 Apr 25. pii: S1566-0702(15)00040-5. doi: 10.1016/j.autneu.2015.04.004. [Epub ahead of print] Adenosine triphosphate (ATP), a transporter of energy in the body, can play a role in key … Continued