New Research Shows How Ketamine Abuse Causes Bladder Damage

Baker SC, Shabir S, Georgopoulos NT, Southgate J. Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress. Am J Pathol. 2016 Mar 16. pii: S0002-9440(16)00073-0. doi: 10.1016/j.ajpath.2015.12.014. [Epub ahead of print] Recent studies … Continued

Pain Pathway Study Reveals Potential New Targets for IC/BPS Treatment

Kouzoukas DE, Ma F, Meyer-Siegler KL, Westlund KN, Hunt DE, Vera PL. Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1. PLoS One. 2016 Mar 24;11(3):e0152055. doi: 10.1371/journal.pone.0152055. eCollection 2016. Because pain is one of the defining symptoms … Continued

Bladder Pain Linked to Changes in Brain Function

Sadler KE, Kolber BJ. Urine trouble: Alterations in brain function associated with bladder pain. J Urol. 2016 Feb 20. pii: S0022-5347(16)00365-7. doi: 10.1016/j.juro.2015.10.198. [Epub ahead of print] The authors of this review article explain a complex network that involves many … Continued

Anti-NGF Therapy: A Potentially Effective Treatment for Bladder Symptoms?

Kawamorita N, Yoshikawa S, Kashyap M, Tyagi P, Arai Y, Chancellor MB, Yoshimura N. Liposome-based Intravesical Therapy targeting Nerve Growth Factor (NGF) ameliorates Bladder Hypersensitivity in Rats with Experimental Colitis. J Urol. 2016 Jan 9. pii: S0022-5347(16)00009-4. doi: 10.1016/j.juro.2015.12.090. [Epub … Continued