Wraps Up with Marker that Could Bring an IC Test Soon
wrapped up IC research presentations here at the American Urological
Association’s (AUA’s) annual meeting with a potential new marker and more.
Research Program funding helped bring about the exciting report in a
“late-breaking news” session of potential new tests for IC. Jason Gilleran, MD,
from Ohio State University in Columbus, working with Tony Buffington, DVM, PhD, is measuring markers in blood with microspectosopy—a light-sensing technique.
All that might be needed for testing is a drop of your blood on a paper card
from a quick finger stick, which gets mailed to the lab for analysis. The markers the researchers
are looking at may be able to show whether you have IC and how severe it is,
which could be very helpful for evaluating new therapies.
have talked about many different potential markers in the last few years, but
none has been developed into a practical test that your doctor could use in the
office. But Dr. Gilleran said that he thinks this test is very amenable to
commercialization. He said the investigators have a partnership with a business
concern at Ohio State, and “We’re going to take this data and some of our
updated data to the FDA to see if we can get this approved for marketing and
analysis and even sale down the road.”
Treatment Talks: Nerve Growth
Factor Inhibitor and Botox
news Tuesday included more detail on the studies of tanezumab, the nerve growth
factor inhibitor, and injection of botulinum toxin A (Botox) injection into
just the lower portion of the bladder (trigone) of IC patients. Researchers are
looking forward to news from the next trial of tanezumab, which is gearing up
now and many of you are enrolling in. Botox given in the trigone looks
promising, decreasing pain and frequency for about nine months at a time.
What’s Happening in the IC
Are your food sensitivities
related to food acid?
An instillation study a few years ago threw doubt on that idea. But this year,
Swedish researchers reported that they have found more active acid sensing
channels in bladder lining and muscle cells of IC patients than in controls. In
the future, these researchers will be looking at how the function of these influence
the “leakiness” of the bladder lining.
Is IC an inflammatory condition?
plenty of debate that has fed the controversy over what to call IC, since some
say there’s no “itis” or inflammation. One study here demonstrated that IC
patients have high levels of C-reactive protein in their bloodstream, which is
considered evidence of chronic inflammation. That doesn’t pinpoint inflammation
to the bladder itself, but the study showed overactive bladder patients had
elevated levels as well, pointing to the bladder as a likely culprit. C-reactive
protein is often used as a marker of inflammation in cardiovascular disease.
it’s not easy to distinguish between IC and overactive bladder, but the
treatments are very different. So, are they really different conditions, and is
there any objective way to tell? There might be, based on a study of markers of
inflammation indicating that each has its own type of inflammation. The
inflammatory protein MCP-1 was much more common in the urine of IC patients,
whereas the inflammatory molecules eotaxin and interleukin 5.
Pudendal or Sacral Nerve? Some studies have shown that
stimulation of the pudendal nerve may be more effective for IC patients than
stimulation of the sacral nerve. A study of the pudendal to bladder reflex
shows that opioid receptors are involved.
A Bump in the Night
have heard some worrying news from this meeting about a link between getting up
to urinate in the night (nocturia) and serious health problems, but the question
is far from settled. People who wake up in the night may be urinating, but that
may not be the reason they’re waking up. The other reasons may carry the health
risks. Furthermore, in a study presented here, the increased for risk heart disease
and death was only in men, with a higher risk of coronary heart disease for men
under 60 and of mortality for men older than age 60. Based on that, you might
expect to see a connection with high blood pressure and diabetes, but there was
none. More research needs to be done.
some IC-friendly snacks and park yourself in front of your computer
screen. There are lots of online videos letting
you experience AUA sessions and events first hand!
ICHelp You Tube Channel—Watch ICA
reports from the AUA
Robert Moldwin, MD, highlights clinician "take-home points" from his course ... more
Linda Salin, answers questions and provides advice for young IC patients... more
Jennifer Fariello, a nurse specializing in women's health, explains the importance of including an examination of the pelvic floor... more
Philip Hanno, MD, gives an overview of the newly-announced American Urological Association treatment guidelines for interstitial cystitis (IC)... more
Philip Hanno, MD explains
the definition of IC and diagnosis approach outlined in the newly
released (preliminary) IC treatment guidelines... more
Check out audio and video
interviews with top experts like Dr. Hanno
Posted June 02, 2010